Ligand id: 242

Name: mosapride

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 76.82
Molecular weight 421.16
XLogP 2.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Bender E, Pindon A, van Oers I, Zhang YB, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W. (2000)
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.
J Neurochem., 74: 478-489. [PMID:10646498]
2. Curran MP, Robinson DM. (2008)
Mosapride in gastrointestinal disorders.
Drugs, 68 (7): 981-91. [PMID:18457463]
3. Tack J, Camilleri M, Chang L, Chey WD, Galligan JJ, Lacy BE, Müller-Lissner S, Quigley EM, Schuurkes J, De Maeyer JH et al.. (2012)
Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.
Aliment. Pharmacol. Ther., 35 (7): 745-67. [PMID:22356640]