Ligand id: 2505

Name: isoflurane

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: isoflurane

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 9.23
Molecular weight 183.97
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Matta JA, Cornett PM, Miyares RL, Abe K, Sahibzada N, Ahern GP. (2008)
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation.
Proc. Natl. Acad. Sci. U.S.A.105 (25): 8784-9. [PMID:18574153]
2. Patel AJ, HonorĂ© E, Lesage F, Fink M, Romey G, Lazdunski M. (1999)
Inhalational anesthetics activate two-pore-domain background K+ channels.
Nat. Neurosci.2 (5): 422-6. [PMID:10321245]