isoflurane

Ligand id: 2505

Name: isoflurane

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 9.23
Molecular weight 183.97
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F. (2001)
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.
Biochem. Biophys. Res. Commun., 282 (1): 249-56. [PMID:11263999]
2. Matta JA, Cornett PM, Miyares RL, Abe K, Sahibzada N, Ahern GP. (2008)
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation.
Proc. Natl. Acad. Sci. U.S.A., 105 (25): 8784-9. [PMID:18574153]
3. Patel AJ, HonorĂ© E, Lesage F, Fink M, Romey G, Lazdunski M. (1999)
Inhalational anesthetics activate two-pore-domain background K+ channels.
Nat. Neurosci., 2 (5): 422-6. [PMID:10321245]
4. Washburn CP, Sirois JE, Talley EM, Guyenet PG, Bayliss DA. (2002)
Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance.
J. Neurosci., 22 (4): 1256-65. [PMID:11850453]