isoflurane

Ligand id: 2505

Name: isoflurane

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: isoflurane

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 9.23
Molecular weight 183.97
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
K2P16.1 Hs Activator - - - 7x10-4 - 9x10-4 1
Conc range: 7x10-4 - 9x10-4 M [1]
TRPA1 Rn Activator Activation 3.7 pEC50 - 2
pEC50 3.7 [2]
Description: Patch clamp
Conditions: HEK293 cells expressing rat TRPA1
K2P3.1 Rn Activator Positive 2.7 pEC50 - 4
pEC50 2.7 [4]
K2P2.1 Hs Activator - - - - 3
studied at 1-5 mM [3]
Ligand mentioned in the following text fields