K<sub>2P</sub>16.1 | Two P domain potassium channels | IUPHAR/BPS Guide to PHARMACOLOGY

K2P16.1

Target id: 525

Nomenclature: K2P16.1

Family: Two P domain potassium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for K2P16.1 in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 2 309 6p21.1-p21.2 KCNK16 potassium two pore domain channel subfamily K member 16 1
Mouse 4 2 292 14 B Kcnk16 potassium channel, subfamily K, member 16
Rat - 2 - 15p16 Kcnk16 potassium two pore domain channel subfamily K member 16
Previous and Unofficial Names
TALK1 | potassium channel, two pore domain subfamily K, member 16 | potassium channel
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Functional Characteristics
Background current

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
isoflurane Hs - - - 7x10-4 - 9x10-4 - 1
Conc range: 7x10-4 - 9x10-4 M [1]
NO Hs - - - - - 1
[1]
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
Ba2+ Hs - - - 1x10-3 - 1
Conc range: 1x10-3 M [1]
chloroform Hs - - - 7x10-4 - 8x10-4 - 1
Conc range: 7x10-4 - 8x10-4 M [1]
quinidine Hs - - - 1x10-4 - 1
Conc range: 1x10-4 M [1]
Tissue Distribution
Placenta.
Species:  Human
Technique:  Northern Blot, cDNA cloning
References:  1-2
Biologically Significant Variant Comments
Alternatively spliced products have been reported but their pharmacological and physiological significance has not been ascertained.
General Comments
‘Activation’ and ‘deactivation’ with voltage steps appear to be instantaneous. The open probability of both K2P16 and 17 increases with external pH. At present it is unclear if this represents proton block at physiological levels or activation of the channel by supra-physiological alkaline pHo. There are four splice variants of K2P16, two of which are functional [2].

References

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1. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F. (2001) Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochem. Biophys. Res. Commun., 282 (1): 249-56. [PMID:11263999]

2. Han J, Kang D, Kim D. (2003) Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. Am. J. Physiol., Cell Physiol., 285 (3): C529-38. [PMID:12724142]

Contributors

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How to cite this page

Leigh D. Plant, Douglas A. Bayliss, Daniel L. Minor, Jr., Gábor Czirják, Péter Enyedi, Florian Lesage, Francisco Sepúlveda, Steve A.N. Goldstein.
Two P domain potassium channels: K2P16.1. Last modified on 09/03/2017. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=525.