Ligand id: 2559

Name: nicardipine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 11
Topological polar surface area 111.01
Molecular weight 479.21
XLogP 6.67
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Hatano N, Ohya S, Muraki K, Giles W, Imaizumi Y. (2003)
Dihydropyridine Ca2+ channel antagonists and agonists block Kv4.2, Kv4.3 and Kv1.4 K+ channels expressed in HEK293 cells.
Br. J. Pharmacol., 139 (3): 533-44. [PMID:12788813]
2. van Rhee AM, Jiang JL, Melman N, Olah ME, Stiles GL, Jacobson KA. (1996)
Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.
J Med Chem, 39: 2980-2989. [PMID:8709132]