amiodarone

Ligand id: 2566

Name: amiodarone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 11
Topological polar surface area 42.68
Molecular weight 645.02
XLogP 7.78
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

References
1. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. (2002)
Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
Eur. J. Hum. Genet.10 (1): 36-43. [PMID:11896454]
2. Sheldon RS, Hill RJ, Cannon NJ, Duff HJ. (1989)
Amiodarone: biochemical evidence for binding to a receptor for class I drugs associated with the rat cardiac sodium channel.
Circ. Res.65 (2): 477-82. [PMID:2546697]