[3H]5-CT

Ligand id: 262

Name: [3H]5-CT    

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 84.9
Molecular weight 203.11
XLogP 0.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Grailhe R, Grabtree GW, Hen R. (2001)
Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution.
Eur J Pharmacol418: 157-167. [PMID:11343685]
2. Thomas DR, Atkinson PJ, Ho M, Bromidge SM, Lovell PJ, Villani AJ, Hagan JJ, Middlemiss DN, Price GW. (2000)
[(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors.
Br. J. Pharmacol.130 (2): 409-17. [PMID:10807680]
3. Waeber C, Grailhe R, Yu XJ, Hen R, Moskowitz MA. (1998)
Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation.
Ann. N. Y. Acad. Sci.861: 85-90. [PMID:9928243]
4. Xie Z, Lee SP, O'Dowd BF, George SR. (1999)
Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed.
FEBS Lett.456 (1): 63-7. [PMID:10452531]