Ligand id: 354

Name: dexetimide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 49.41
Molecular weight 362.2
XLogP 5.87
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Dom R, Van Lommel R, Baro F. (1971)
A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent.
Acta Psychiatr Scand, 47 (4): 399-410. [PMID:4947805]
2. Huygens H, Vereecken JL, Tanghe A. (1973)
Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action.
Psychiatr Neurol Neurochir, 76 (4): 251-9. [PMID:4581374]
3. Kovacs I, Yamamura HI, Waite SL, Varga EV, Roeske WR. (1998)
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
J Pharmacol Exp Ther, 284: 500-507. [PMID:9454790]