Dickkopf 1

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Ligands
Dickkopf 1 (Human)

GtoPdb Ligand ID: 3701

Synonyms: Dickkopf-related protein 1 | DKK 1

Compound class: Endogenous peptide in human, mouse or rat

Comment: DKK1 is a secreted protein that inhibits canonical Wnt/β-catenin signalling via interaction with the LRP5/LRP6 co-receptor. It is involved in normal biological processes such as embryonic development and bone homeostasis [5]. In the cancer setting DKK1 promotes an immunosuppressive tumour microenvironment [3,6], and is associated with cancer cell proliferation, invasion, and tumour growth [1,4]. Neutralising DKK1 function is being investigated as an oncology therapeutic strategy.

Species: Human

References
1. D'Amico L, Mahajan S, Capietto AH, Yang Z, Zamani A, Ricci B, Bumpass DB, Meyer M, Su X, Wang-Gillam A et al.. (2016) Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer. J Exp Med, 213 (5): 827-40. [PMID:27045006]
2. Katoh M, Katoh M. (2017) Molecular genetics and targeted therapy of WNT-related human diseases (Review). Int J Mol Med, 40 (3): 587-606. [PMID:28731148]
3. MacDonald BT, Joiner DM, Oyserman SM, Sharma P, Goldstein SA, He X, Hauschka PV. (2007) Bone mass is inversely proportional to Dkk1 levels in mice. Bone, 41 (3): 331-9. [PMID:17613296]
4. Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y, de Stanchina E, Massagué J. (2016) Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT. Cell, 165 (1): 45-60. [PMID:27015306]
5. Pinzone JJ, Hall BM, Thudi NK, Vonau M, Qiang YW, Rosol TJ, Shaughnessy Jr JD. (2009) The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood, 113 (3): 517-25. [PMID:18687985]
6. Shi RY, Yang XR, Shen QJ, Yang LX, Xu Y, Qiu SJ, Sun YF, Zhang X, Wang Z, Zhu K et al.. (2013) High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery. Cancer, 119 (5): 993-1003. [PMID:23132676]

References

1. D'Amico L, Mahajan S, Capietto AH, Yang Z, Zamani A, Ricci B, Bumpass DB, Meyer M, Su X, Wang-Gillam A et al.. (2016)
Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer.
J Exp Med, 213 (5): 827-40. [PMID:27045006]

2. Katoh M, Katoh M. (2017)
Molecular genetics and targeted therapy of WNT-related human diseases (Review).
Int J Mol Med, 40 (3): 587-606. [PMID:28731148]

3. MacDonald BT, Joiner DM, Oyserman SM, Sharma P, Goldstein SA, He X, Hauschka PV. (2007)
Bone mass is inversely proportional to Dkk1 levels in mice.
Bone, 41 (3): 331-9. [PMID:17613296]

4. Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y, de Stanchina E, Massagué J. (2016)
Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.
Cell, 165 (1): 45-60. [PMID:27015306]

5. Pinzone JJ, Hall BM, Thudi NK, Vonau M, Qiang YW, Rosol TJ, Shaughnessy Jr JD. (2009)
The role of Dickkopf-1 in bone development, homeostasis, and disease.
Blood, 113 (3): 517-25. [PMID:18687985]

6. Shi RY, Yang XR, Shen QJ, Yang LX, Xu Y, Qiu SJ, Sun YF, Zhang X, Wang Z, Zhu K et al.. (2013)
High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery.
Cancer, 119 (5): 993-1003. [PMID:23132676]