[3H]DPCPX

Ligand id: 406

Name: [3H]DPCPX    

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 69.3
Molecular weight 304.19
XLogP 3.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Dalpiaz A, Townsend-Nicholson A, Beukers MW, Schofield PR, Ijzerman AP. (1998)
Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors.
Biochem Pharmacol56: 1437-1445. [PMID:9827575]
2. Feoktistov I, Garland EM, Goldstein AE, Zeng D, Belardinelli L, Wells JN, Biaggioni I. (2001)
Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2).
Biochem Pharmacol62: 1163-1173. [PMID:11705449]
3. Klotz K-N, Hessling J, Hegler J, Owman C, Kull B, Fredholm BB, Lohse MJ. (1998)
Comparative pharmacology of human adenosine receptor subtypes characterization of stably transfected receptors in CHO cells.
Naunyn Schmiedebergs Arch. Pharmacol.357: 1-9. [PMID:9459566]
4. Ongini E, Dionisotti S, Gessi S, Irenius E, Fredholm BB. (1999)
Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.
Naunyn Schmiedebergs Arch. Pharmacol.359: 7-10. [PMID:9933143]
5. Rivkees SA, Barbhaiya H, Ijzerman AP. (1999)
Identification of the adenine binding site of the human A1 adenosine receptor.
J. Biol. Chem.274: 3617-3621. [PMID:9920910]
6. Stewart M, Steinig AG, Ma C, Song JP, McKibben B, Castelhano AL, MacLennan SJ. (2004)
[3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors.
Biochem Pharmacol68: 305-312. [PMID:15194002]
7. Townsend-Nicholson A, Schofield PR. (1994)
A threonine residue in the seventh transmembrane domain of the human A1 adenosine receptor mediates specific agonist binding.
J Biol Chem269: 2373-2376. [PMID:8300561]