Ligand id: 4253

Name: memantine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 26.02
Molecular weight 179.17
XLogP 3.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Sani G, Serra G, Kotzalidis GD, Romano S, Tamorri SM, Manfredi G, Caloro M, Telesforo CL, Caltagirone SS, Panaccione I et al.. (2012)
The role of memantine in the treatment of psychiatric disorders other than the dementias: a review of current preclinical and clinical evidence.
CNS Drugs, 26 (8): 663-90. [PMID:22784018]
2. Wilkinson D, Wirth Y, Goebel C. (2014)
Memantine in patients with moderate to severe Alzheimer's disease: meta-analyses using realistic definitions of response.
Dement Geriatr Cogn Disord, 37 (1-2): 71-85. [PMID:24107324]