Ligand id: 4253

Name: memantine

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View more information in the IUPHAR Pharmacology Education Project: memantine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 26.02
Molecular weight 179.17
XLogP 3.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Memantine reduces clinical worsening in moderate to severe AD [2].
Memantine is a component of the approved AD fixed-dose medication Namzaric® (which contains memantine plus donepezil).
Mechanism Of Action and Pharmacodynamic Effects
Memantine blocks NMDA glutamate channels. For a complete overview of the mechanism of action of memantine, please see the DrugBank link on the Summary tab of this ligand page..