isradipine

Ligand id: 4488

Name: isradipine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 103.55
Molecular weight 371.15
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Baumann L, Gerstner A, Zong X, Biel M, Wahl-Schott C. (2004)
Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina.
Invest. Ophthalmol. Vis. Sci.45 (2): 708-13. [PMID:14744918]
2. Koschak A, Reimer D, Huber I, Grabner M, Glossmann H, Engel J, Striessnig J. (2001)
alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages.
J. Biol. Chem.276 (25): 22100-6. [PMID:11285265]
3. Koschak A, Reimer D, Walter D, Hoda JC, Heinzle T, Grabner M, Striessnig J. (2003)
Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.
J. Neurosci.23 (14): 6041-9. [PMID:12853422]
4. Sinnegger-Brauns MJ, Hetzenauer A, Huber IG, Renstr├Âm E, Wietzorrek G, Berjukov S, Cavalli M, Walter D, Koschak A, Waldsch├╝tz R, Hering S, Bova S, Rorsman P, Pongs O, Singewald N, Striessnig J J. (2004)
Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels.
J. Clin. Invest.113 (10): 1430-9. [PMID:15146240]
5. Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J. (2009)
Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.
Mol. Pharmacol.75 (2): 407-14. [PMID:19029287]