Ligand id: 4985

Name: IL-2

Species: Human

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View more information in the IUPHAR Pharmacology Education Project: interleukin-2

1. Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC. (2003)
Discovery of a potent small molecule IL-2 inhibitor through fragment assembly.
J. Am. Chem. Soc., 125 (13): 3714-5. [PMID:12656598]
2. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. (2005)
A function for interleukin 2 in Foxp3-expressing regulatory T cells.
Nat. Immunol., 6 (11): 1142-51. [PMID:16227984]
3. Klatzmann D, Abbas AK. (2015)
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases.
Nat. Rev. Immunol., 15 (5): 283-94. [PMID:25882245]
4. Waldmann TA. (2006)
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design.
Nat. Rev. Immunol., 6 (8): 595-601. [PMID:16868550]