dexmedetomidine

Ligand id: 521

Name: dexmedetomidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 28.68
Molecular weight 200.13
XLogP 4.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Jasper JR, Lesnick JD, Chang LK, Yamanishi SS, Chang TK, Hsu SAO, Daunt DA, Bonhaus DW, Eglen RM. (1998)
Ligand efficacy and potency at recombinant alpha 2 adrenergic receptors - Agonist-mediated [35S]GTPgammaS binding.
Biochem Pharmacol.55: 1035-1043. [PMID:9605427]
2. MacDonald E, Kobilka BK, Scheinin M. (1997)
Gene targeting--homing in on alpha 2-adrenoceptor-subtype function.
Trends Pharmacol. Sci.18 (6): 211-9. [PMID:9227000]
3. Peltonen JM, Pihlavisto M, Scheinin M. (1998)
Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha-2 adrenoceptors.
Eur J Pharmacol.355: 275-279. [PMID:9760042]
4. Pihlavisto M, Sjöholm B, Scheinin M, Wurster S. (1998)
Modulation of agonist binding to recombinant human alpha-2 adrenoceptors by sodium ions.
Biochim Biophys Acta Mol Cell Res.1448: 135-146. [PMID:9824686]