Ligand id: 5257

Name: riociguat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 138.07
Molecular weight 422.16
XLogP 2.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Stasch JP, Becker EM, Alonso-Alija C, Apeler H, Dembowsky K, Feurer A, Gerzer R, Minuth T, Perzborn E, Pleiss U et al.. (2001)
NO-independent regulatory site on soluble guanylate cyclase.
Nature, 410 (6825): 212-5. [PMID:11242081]
2. Stasch JP, Hobbs AJ. (2009)
NO-independent, haem-dependent soluble guanylate cyclase stimulators.
Handb Exp Pharmacol, (191): 277-308. [PMID:19089334]