Ligand id: 6326

Name: tranilast

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 84.86
Molecular weight 327.11
XLogP 3.75
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Baba A, Tachi M, Ejima Y, Endo Y, Toyama H, Matsubara M, Saito K, Yamauchi M, Miura C, Kazama I. (2016)
Anti-Allergic Drugs Tranilast and Ketotifen Dose-Dependently Exert Mast Cell-Stabilizing Properties.
Cell. Physiol. Biochem., 38 (1): 15-27. [PMID:26741745]
2. Nakajima Y, Itoh T, Morino Y. (2016)
Metal allergy to everolimus-eluting cobalt chromium stents confirmed by positive skin testing as a cause of recurrent multivessel in-stent restenosis.
Catheter Cardiovasc Interv, 87 (4): 137-142. [PMID:26011018]
3. Zampini P, Riviera AP, Tridente G. (1983)
In vitro inhibition of histamine release from mouse mast cells and human basophils by an anthranilic acid derivative.
Int. J. Immunopharmacol., 5 (5): 431-5. [PMID:6197383]