tadalafil

Ligand id: 7299

Name: tadalafil

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 74.87
Molecular weight 389.14
XLogP 2.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Forgue ST, Patterson BE, Bedding AW, Payne CD, Phillips DL, Wrishko RE, Mitchell MI. (2006)
Tadalafil pharmacokinetics in healthy subjects.
Br J Clin Pharmacol61 (3): 280-8. [PMID:16487221]
2. Mohamed HA, Girgis NM, Wilcken R, Bauer MR, Tinsley HN, Gary BD, Piazza GA, Boeckler FM, Abadi AH. (2011)
Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.
J. Med. Chem.54 (2): 495-509. [PMID:21189023]