Ligand id: 7320

Name: vardenafil

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 117.18
Molecular weight 489.23
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Boyle CD, Xu R, Asberom T, Chackalamannil S, Clader JW, Greenlee WJ, Guzik H, Hu Y, Hu Z, Lankin CM et al.. (2005)
Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.
Bioorg. Med. Chem. Lett., 15 (9): 2365-9. [PMID:15837326]