Ligand id: 7327

Name: thalidomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 87.04
Molecular weight 258.06
XLogP 1.35
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

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Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.
Nat. Med., 22 (7): 735-43. [PMID:27294876]
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Identification of a primary target of thalidomide teratogenicity.
Science, 327 (5971): 1345-50. [PMID:20223979]
3. Jo S, Lee KH, Song S, Jung YK, Park CS. (2005)
Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain.
J. Neurochem., 94 (5): 1212-24. [PMID:16045448]
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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.
Leukemia, 26 (11): 2326-35. [PMID:22552008]
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Novel thalidomide analogues from diamines inhibit pro-inflammatory cytokine production and CD80 expression while enhancing IL-10.
Biomed. Pharmacother., 66 (5): 323-9. [PMID:22770990]
6. Xin W, Xiaohua N, Peilin C, Xin C, Yaqiong S, Qihan W. (2008)
Primary function analysis of human mental retardation related gene CRBN.
Mol. Biol. Rep., 35 (2): 251-6. [PMID:17380424]