lenalidomide

Ligand id: 7331

Name: lenalidomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 95.99
Molecular weight 259.1
XLogP 0.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Matyskiela ME, Zhang W, Man HW, Muller G, Khambatta G, Baculi F, Hickman M, LeBrun L, Pagarigan B, Carmel G et al.. (2017)
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J. Med. Chem.,  [Epub ahead of print]. [PMID:28425720]
2. Zhu YX, Braggio E, Shi CX, Bruins LA, Schmidt JE, Van Wier S, Chang XB, Bjorklund CC, Fonseca R, Bergsagel PL et al.. (2011)
Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.
Blood118 (18): 4771-9. [PMID:21860026]