Ligand id: 7356

Name: cerlapirdine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.67
Molecular weight 409.15
XLogP 5.06
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Bernotas, Ronald Charles et al.. (2007)
Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands.
Patent number: WO2007021711. Assignee: Wyeth (now Pfizer). Priority date: 15/08/2005. Publication date: 22/02/2007.
2. Codony X, Vela JM, Ramírez MJ. (2011)
5-HT(6) receptor and cognition.
Curr Opin Pharmacol, 11 (1): 94-100. [PMID:21330210]
3. Commery TA. (2010)
SAM-531, N,N-dimethyl-3-{[3-(1-naphthylsulfonyl)-1H-indazol-5-yl]oxy} propan-1-amine, a novel serotonin-6 receptor antagonist with preclinical pro-cognitive efficacy.
Alzheimer's & Dementia, 6 (4): S548-S549.