blinatumomab

Ligand id: 7384

Name: blinatumomab

References
1. Brischwein K, Parr L, Pflanz S, Volkland J, Lumsden J, Klinger M, Locher M, Hammond SA, Kiener P, Kufer P et al.. (2007)
Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class.
J. Immunother.30 (8): 798-807. [PMID:18049331]
2. Dreier T, Lorenczewski G, Brandl C, Hoffmann P, Syring U, Hanakam F, Kufer P, Riethmuller G, Bargou R, Baeuerle PA. (2002)
Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody.
Int. J. Cancer100 (6): 690-7. [PMID:12209608]
3. Kufer P, Lutterbuse R, Kohleisen B, Zeman S, Bauerle P. (2009)
Single chain antibody construct comprising binding domains specific for human CD3 and human CD19.
Patent number: US7635472. Assignee: Micromet Ag. Priority date: 31/05/2003. Publication date: 22/12/2009.
4. Mølhøj M, Crommer S, Brischwein K, Rau D, Sriskandarajah M, Hoffmann P, Kufer P, Hofmeister R, Baeuerle PA. (2007)
CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis.
Mol. Immunol.44 (8): 1935-43. [PMID:17083975]