Ligand id: 743

Name: rimonabant

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 50.16
Molecular weight 462.08
XLogP 5.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

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LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation.
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GPR55 ligands promote receptor coupling to multiple signalling pathways.
Br. J. Pharmacol., 160 (3): 604-14. [PMID:20136841]
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SR141716A, a potent and selective antagonist of the brain cannabinoid receptor.
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Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor.
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7. Showalter VM, Compton DR, Martin BR, Abood ME. (1996)
Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands.
J. Pharmacol. Exp. Ther., 278: 989-999. [PMID:8819477]