Synonyms: BB-10901 | IMGN901
Compound class:
Antibody
Comment: Lorvotuzumab mertansine is an antibody-drug conjugate (ADC) combining an anti-NCAM1 (CD56) monoclonal antibody with the maytansinoid DM1 (PubChem CID 71301226) tubulin inhibitor [2].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-db record. Patent US5639641 [4] describes the resurfacing of murine anti-CD56 monoclonal antibody N901, to improve its therapeutic efficacy in preparation for use as a human drug. A protein BLAST search matches the variable region of the light chain of lorvotuzumab, with sequence 36 from the patent, sequence 36 being a CDR grafted version of N901. No affinity data for the interaction between the preferred engineered antibody and the molecular target is provided in the patent. |
References |
1. Ishitsuka K, Jimi S, Goldmacher VS, Ab O, Tamura K. (2008)
Targeting CD56 by the maytansinoid immunoconjugate IMGN901 (huN901-DM1): a potential therapeutic modality implication against natural killer/T cell malignancy. Br J Haematol, 141 (1): 129-31. [PMID:18279455] |
2. Lambert JM. (2013)
Drug-conjugated antibodies for the treatment of cancer. Br J Clin Pharmacol, 76 (2): 248-62. [PMID:23173552] |
3. Lutz RJ, Whiteman KR. (2009)
Antibody-maytansinoid conjugates for the treatment of myeloma. MAbs, 1 (6): 548-51. [PMID:20068397] |
4. Pedersen JT, Searle SMJ, Rees AR, Roguska MA, Guild BC. (1997)
Resurfacing of rodent antibodies. Patent number: US5639641. Assignee: Immunogen Inc.. Priority date: 09/09/1999. Publication date: 17/06/1997. |
5. van de Donk NW, Lokhorst HM. (2013)
New developments in the management and treatment of newly diagnosed and relapsed/refractory multiple myeloma patients. Expert Opin Pharmacother, 14 (12): 1569-73. [PMID:23721099] |
6. Whiteman KR, Johnson HA, Mayo MF, Audette CA, Carrigan CN, LaBelle A, Zukerberg L, Lambert JM, Lutz RJ. (2014)
Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models. MAbs, 6 (2): 556-66. [PMID:24492307] |