Synonyms: (+)-alpha-propoxyphene | Darvon® | propoxyphene
dextropropoxyphene is an approved drug
Compound class:
Synthetic organic
Comment: Dextropropoxyphene is principally an opioid analgesic. Chemically it is an optical isomer of levopropoxyphene (the (2R,3S) optical isomer with PubChem CID 200742); dextropropoxyphene being the (2S,3R) enantiomer. Marketing in Europe and the US has been discontinued due to concerns of fatal overdoses and heart arrhythmias.
|
|
References |
1. Xiao Y, Smith RD, Caruso FS, Kellar KJ. (2001)
Blockade of rat alpha3beta4 nicotinic receptor function by methadone, its metabolites, and structural analogs. J Pharmacol Exp Ther, 299 (1): 366-71. [PMID:11561100] |