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Synonyms: Leukine®
sargramostim is an approved drug (FDA (1991))
Compound class:
Peptide or derivative
Comment: Sargramostim is recombinant human GM-CSF, produced in E.coli. Compared to the endogenous peptide sargramostim has a Arg>Leu substitution at residue 23.
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| References |
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1. Hodi FS, Lee S, McDermott DF, Rao UN, Butterfield LH, Tarhini AA, Leming P, Puzanov I, Shin D, Kirkwood JM. (2014)
Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial. JAMA, 312 (17): 1744-53. [PMID:25369488] |
