mitumomab   Click here for help

GtoPdb Ligand ID: 7981

Synonyms: monoclonal antibody BEC2
Compound class: Antibody
Comment: Mitumomab (BEC2) is an anti-idiotypic monoclonal antibody that mimics GD3 ganglioside and is being tested as a vaccination therapy in oncology.
References
1. Chapman PB, Houghton AN. (1991)
Induction of IgG antibodies against GD3 ganglioside in rabbits by an anti-idiotypic monoclonal antibody.
J Clin Invest, 88 (1): 186-92. [PMID:2056117]
2. Fredman P, Hedberg K, Brezicka T. (2003)
Gangliosides as therapeutic targets for cancer.
BioDrugs, 17 (3): 155-67. [PMID:12749752]
3. Hernández AM, Rodríguez N, González JE, Reyes E, Rondón T, Griñán T, Macías A, Alfonso S, Vázquez AM, Pérez R. (2011)
Anti-NeuGcGM3 antibodies, actively elicited by idiotypic vaccination in nonsmall cell lung cancer patients, induce tumor cell death by an oncosis-like mechanism.
J Immunol, 186 (6): 3735-44. [PMID:21300821]
4. McCaffery M, Yao TJ, Williams L, Livingston PO, Houghton AN, Chapman PB. (1996)
Immunization of melanoma patients with BEC2 anti-idiotypic monoclonal antibody that mimics GD3 ganglioside: enhanced immunogenicity when combined with adjuvant.
Clin Cancer Res, 2 (4): 679-86. [PMID:9816218]