Synonyms: monoclonal antibody BEC2
Compound class:
Antibody
Comment: Mitumomab (BEC2) is an anti-idiotypic monoclonal antibody that mimics GD3 ganglioside and is being tested as a vaccination therapy in oncology.
|
References |
1. Chapman PB, Houghton AN. (1991)
Induction of IgG antibodies against GD3 ganglioside in rabbits by an anti-idiotypic monoclonal antibody. J Clin Invest, 88 (1): 186-92. [PMID:2056117] |
2. Fredman P, Hedberg K, Brezicka T. (2003)
Gangliosides as therapeutic targets for cancer. BioDrugs, 17 (3): 155-67. [PMID:12749752] |
3. Hernández AM, Rodríguez N, González JE, Reyes E, Rondón T, Griñán T, Macías A, Alfonso S, Vázquez AM, Pérez R. (2011)
Anti-NeuGcGM3 antibodies, actively elicited by idiotypic vaccination in nonsmall cell lung cancer patients, induce tumor cell death by an oncosis-like mechanism. J Immunol, 186 (6): 3735-44. [PMID:21300821] |
4. McCaffery M, Yao TJ, Williams L, Livingston PO, Houghton AN, Chapman PB. (1996)
Immunization of melanoma patients with BEC2 anti-idiotypic monoclonal antibody that mimics GD3 ganglioside: enhanced immunogenicity when combined with adjuvant. Clin Cancer Res, 2 (4): 679-86. [PMID:9816218] |