guselkumab

Ligand id: 7998

Name: guselkumab

References
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Human anti-IL-23 antibodies, compositions, methods and uses.
Patent number: US7935344. Assignee: Centocor Ortho Biotech Inc.. Priority date: 29/12/2005. Publication date: 01/05/2011.
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IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.
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Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation.
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Guselkumab (an IL-23-specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis.
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