BMS-214662

Ligand id: 8026

Name: BMS-214662

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 129.71
Molecular weight 489.13
XLogP 5.32
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Downward J. (2003)
Targeting RAS signalling pathways in cancer therapy.
Nat. Rev. Cancer3 (1): 11-22. [PMID:12509763]
2. Hunt JT, Ding CZ, Batorsky R, Bednarz M, Bhide R, Cho Y, Chong S, Chao S, Gullo-Brown J, Guo P et al.. (2000)
Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.
J. Med. Chem.43 (20): 3587-95. [PMID:11020273]