compound 15b [PMID: 16539403]

Ligand id: 8194

Name: compound 15b [PMID: 16539403]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 68.76
Molecular weight 359.17
XLogP 2.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Li HY, Wang Y, Heap CR, King CH, Mundla SR, Voss M, Clawson DK, Yan L, Campbell RM, Anderson BD et al.. (2006)
Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7.
J. Med. Chem., 49 (6): 2138-42. [PMID:16539403]