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Synonyms: GSK-1223249 | GSK1223249
Compound class:
Antibody
Comment: Ozanezumab is a humanised mouse monoclonal antibody targeting NOGO-A (reticulon-4, RTN4). This antibody is in GlaxoSmithKline's development pipeline of drugs for rare diseases, in this case amyotrophic lateral sclerosis (ALS aka motor neurone disease or MND) and was also investigated for multiple sclerosis (MS).
Although peptide sequences for ozanezumab are available, a BLAST search provided no exact matches with patented protein sequences 
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Caroni P, Schwab ME. (1988)
Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron, 1 (1): 85-96. [PMID:3272156] |
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2. Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME. (2000)
Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature, 403 (6768): 434-9. [PMID:10667796] |
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3. Clegg SJ, Ellis JH, Germaschewski V, Hamblin PA, Kopsidas G, Mcadam R, Prinjha RK. (2007)
Immunoglobulins. Patent number: US8362208. Assignee: Glaxo Group Ltd , Clegg SJ, Ellis JH, Germaschewski V, Hamblin PA, Kopsidas G, Mcadam R, Prinjha RK. Priority date: 16/12/2005. Publication date: 29/11/2007. |
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4. Jokic N, Gonzalez de Aguilar JL, Dimou L, Lin S, Fergani A, Ruegg MA, Schwab ME, Dupuis L, Loeffler JP. (2006)
The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. EMBO Rep, 7 (11): 1162-7. [PMID:17039253] |
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5. Schmidt ER, Pasterkamp RJ, van den Berg LH. (2009)
Axon guidance proteins: novel therapeutic targets for ALS?. Prog Neurobiol, 88 (4): 286-301. [PMID:19523502] |
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6. Schnell L, Schwab ME. (1990)
Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature, 343 (6255): 269-72. [PMID:2300171] |
