example 373 [WO2012093101]

Ligand id: 8296

Name: example 373 [WO2012093101]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 142.48
Molecular weight 524.14
XLogP 1.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Abdel-Magid AF. (2012)
Factor D Inhibitors for the Treatment of AMD: Patent Highlight.
ACS Med Chem Lett, 3 (10): 781-2. [PMID:24900375]
2. Altmann E, Hommel U, Lorthiois ELJ, Maibaum JK, Ostermann N, Quancard J, Randl SA, Rogel O, Simic O, Vulpetti A. (2012)
Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD).
Patent number: WO2012093101. Assignee: Novartis Ag. Priority date: 04/01/2011. Publication date: 12/07/2012.