ABT-737

Ligand id: 8320

Name: ABT-737

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 17
Topological polar surface area 161.81
Molecular weight 812.26
XLogP 11.14
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

References
1. Amundson SA, Myers TG, Scudiero D, Kitada S, Reed JC, Fornace Jr AJ. (2000)
An informatics approach identifying markers of chemosensitivity in human cancer cell lines.
Cancer Res.60 (21): 6101-10. [PMID:11085534]
2. Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC et al.. (2007)
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
J. Med. Chem.50 (4): 641-62. [PMID:17256834]
3. Green DR, Evan GI. (2002)
A matter of life and death.
Cancer Cell1 (1): 19-30. [PMID:12086884]
4. Jain HV, Meyer-Hermann M. (2011)
The molecular basis of synergism between carboplatin and ABT-737 therapy targeting ovarian carcinomas.
Cancer Res.71 (3): 705-15. [PMID:21169413]
5. Lheureux S, N'Diaye M, Blanc-Fournier C, DuguĂ© AE, Clarisse B, Dutoit S, Giffard F, Abeilard E, Briand M, Labiche A et al.. (2015)
Identification of predictive factors of response to the BH3-mimetic molecule ABT-737: an ex vivo experiment in human serous ovarian carcinoma.
Int. J. Cancer136 (5): E340-50. [PMID:25066666]
6. Tian BP, Xia LX, Bao ZQ, Zhang H, Xu ZW, Mao YY, Cao C, Che LQ, Liu JK, Li W et al.. (2016)
Bcl-2 Inhibitors Reduce Steroid-insensitive Airway Inflammation.
J. Allergy Clin. Immunol.,  [Epub ahead of print]. [PMID:28043871]
7. Witham J, Valenti MR, De-Haven-Brandon AK, Vidot S, Eccles SA, Kaye SB, Richardson A. (2007)
The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin.
Clin. Cancer Res.13 (23): 7191-8. [PMID:18056200]