ertugliflozin

Ligand id: 8376

Name: ertugliflozin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 108.61
Molecular weight 436.13
XLogP 3.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Bays H. (2009)
From victim to ally: the kidney as an emerging target for the treatment of diabetes mellitus.
Curr Med Res Opin25 (3): 671-81. [PMID:19232040]
2. Mascitti V, Maurer TS, Robinson RP, Bian J, Boustany-Kari CM, Brandt T, Collman BM, Kalgutkar AS, Klenotic MK, Leininger MT et al.. (2011)
Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors.
J. Med. Chem.54 (8): 2952-60. [PMID:21449606]
3. Nair S, Wilding JP. (2010)
Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus.
J. Clin. Endocrinol. Metab.95 (1): 34-42. [PMID:19892839]