EPZ005687

Ligand id: 8387

Name: EPZ005687

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 88.49
Molecular weight 539.29
XLogP 5.24
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Knutson SK, Wigle TJ, Warholic NM, Sneeringer CJ, Allain CJ, Klaus CR, Sacks JD, Raimondi A, Majer CR, Song J et al.. (2012)
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
Nat. Chem. Biol.8 (11): 890-6. [PMID:23023262]