DS-437

Ligand id: 8395

Name: DS-437

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 5
Rotatable bonds 9
Topological polar surface area 185.74
Molecular weight 397.15
XLogP -1
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Bezzi M, Teo SX, Muller J, Mok WC, Sahu SK, Vardy LA, Bonday ZQ, Guccione E. (2013)
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery.
Genes Dev.27 (17): 1903-16. [PMID:24013503]
2. Meister G, Eggert C, B├╝hler D, Brahms H, Kambach C, Fischer U. (2001)
Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.
Curr. Biol.11 (24): 1990-4. [PMID:11747828]
3. Smil D, Eram MS, Li F, Kennedy S, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. (2015)
Discovery of a Dual PRMT5-PRMT7 Inhibitor.
ACS Med Chem Lett6 (4): 408-12. [PMID:25893041]
4. Yan F, Alinari L, Lustberg ME, Martin LK, Cordero-Nieves HM, Banasavadi-Siddegowda Y, Virk S, Barnholtz-Sloan J, Bell EH, Wojton J et al.. (2014)
Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.
Cancer Res.74 (6): 1752-65. [PMID:24453002]
5. Yao R, Jiang H, Ma Y, Wang L, Wang L, Du J, Hou P, Gao Y, Zhao L, Wang G et al.. (2014)
PRMT7 induces epithelial-to-mesenchymal transition and promotes metastasis in breast cancer.
Cancer Res.74 (19): 5656-67. [PMID:25136067]