beloranib

Ligand id: 8445

Name: beloranib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 12
Topological polar surface area 73.06
Molecular weight 499.29
XLogP 4.49
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Chun E, Han CK, Yoon JH, Sim TB, Kim YK, Lee KY. (2005)
Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model.
Int. J. Cancer114 (1): 124-30. [PMID:15523682]
2. Joharapurkar AA, Dhanesha NA, Jain MR. (2014)
Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity.
Diabetes Metab Syndr Obes7: 73-84. [PMID:24611021]
3. Kim YM, An JJ, Jin YJ, Rhee Y, Cha BS, Lee HC, Lim SK. (2007)
Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732.
J. Mol. Endocrinol.38 (4): 455-65. [PMID:17446235]
4. Lee HS, Choi WK, Son HJ, Lee SS, Kim JK, Ahn SK, Hong CI, Min HK, Kim M, Myung SW. (2004)
Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs.
Arch. Pharm. Res.27 (2): 265-72. [PMID:15029870]
5. Shin SJ, Ahn JB, Park KS, Lee YJ, Hong YS, Kim TW, Kim HR, Rha SY, Roh JK, Kim DH et al.. (2012)
A Phase Ib pharmacokinetic study of the anti-angiogenic agent CKD-732 used in combination with capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer patients who progressed on irinotecan-based chemotherapy.
Invest New Drugs30 (2): 672-80. [PMID:21188464]
6. Yin SQ, Wang JJ, Zhang CM, Liu ZP. (2012)
The development of MetAP-2 inhibitors in cancer treatment.
Curr. Med. Chem.19 (7): 1021-35. [PMID:22229417]