BIA 10-2474

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Ligands
BIA 10-2474

Ligand id: 9001

Name: BIA 10-2474

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	4
Topological polar surface area	65.07
Molecular weight	300.16
XLogP	1.72
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

References
1. Kiss LE et al.. (2010) Pharmaceutical compounds. Patent number: WO2010074588 A2. Assignee: BIAL- PORTELA & Cª, S.A. Priority date: 24/12/2008. Publication date: 01/07/2010.
2. Kiss LE, Learmonth DA, Da Costa Pereira Rosa CP, Gusmao De Norohna NR, Palma PNL, Soares Da Silva PMVA, Beliaev A. (2011) Pharmaceutical compounds. Patent number: WO2010074588 A8. Assignee: BIAL-PORTELA and C^A, S.A.. Priority date: 23/12/2008. Publication date: 06/10/2011.
3. Lodola A, Castelli R, Mor M, Rivara S. (2015) Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014). Expert Opin Ther Pat, 25 (11): 1247-66. [PMID:26413912]
4. Sałaga M, Sobczak M, Fichna J. (2014) Inhibition of fatty acid amide hydrolase (FAAH) as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract. Eur J Pharm Sci, 52: 173-9. [PMID:24275607]
5. Ulugöl A. (2014) The endocannabinoid system as a potential therapeutic target for pain modulation. Balkan Med J, 31 (2): 115-20. [PMID:25207181]
6. van Esbroeck ACM, Janssen APA, Cognetta 3rd AB, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H et al.. (2017) Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science, 356 (6342): 1084-1087. [PMID:28596366]

References

1. Kiss LE et al.. (2010)
Pharmaceutical compounds.
Patent number: WO2010074588 A2. Assignee: BIAL- PORTELA & Cª, S.A. Priority date: 24/12/2008. Publication date: 01/07/2010.

2. Kiss LE, Learmonth DA, Da Costa Pereira Rosa CP, Gusmao De Norohna NR, Palma PNL, Soares Da Silva PMVA, Beliaev A. (2011)
Pharmaceutical compounds.
Patent number: WO2010074588 A8. Assignee: BIAL-PORTELA and C^A, S.A.. Priority date: 23/12/2008. Publication date: 06/10/2011.

3. Lodola A, Castelli R, Mor M, Rivara S. (2015)
Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014).
Expert Opin Ther Pat, 25 (11): 1247-66. [PMID:26413912]

4. Sałaga M, Sobczak M, Fichna J. (2014)
Inhibition of fatty acid amide hydrolase (FAAH) as a novel therapeutic strategy in the treatment of pain and inflammatory diseases in the gastrointestinal tract.
Eur J Pharm Sci, 52: 173-9. [PMID:24275607]

5. Ulugöl A. (2014)
The endocannabinoid system as a potential therapeutic target for pain modulation.
Balkan Med J, 31 (2): 115-20. [PMID:25207181]

6. van Esbroeck ACM, Janssen APA, Cognetta 3rd AB, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H et al.. (2017)
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.
Science, 356 (6342): 1084-1087. [PMID:28596366]