BIA 10-2474

Ligand id: 9001

Name: BIA 10-2474

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 65.07
Molecular weight 300.16
XLogP 1.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
FAAH is a serine hydrolase enzyme of the endocannabinoid system which is responsible for the catabolic inactivation of the neuromodulator anandamide. FAAH inhibitors cause a build up of anandamide, which acts through activation of cannabinoid receptors to promote analgesia. Percentage inhibition data is reported in WO2010074588 [1], with rat brain FAAH inhibited by 78.2% at 100nM compound in vitro.
BIA 10-2474 does not interact with other proteins of the endocannabinoid system or with the endocannabinoid-binding transient receptor potential (TRP) ion channels [6].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Fatty acid amide hydrolase Inhibitor Inhibition 7.2 – 7.3 pIC50 - 6
pIC50 7.2 – 7.3 (IC50 7x10-8 – 5x10-8 M) [6]
Description: Inhibition of human FAAH expressed in HEK293T cells.
Selectivity at rat enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Fatty acid amide hydrolase Inhibitor Inhibition ~6.7 pIC50 - 1
pIC50 ~6.7 (IC50 ~2x10-7 M) [1]
Description: This value is an extrapolated estimate from % inhibition data provided in Table 1 of the referenced patent.