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Synonyms: OPN 7486 | OPN-7486 | PLX-7486
Compound class:
Synthetic organic
Comment: PLX7486 is a small molecule CSF1R/TRK/Fms kinases inhibitor. It is orally available, potent and selective, with attractive pharmaceutical properties and is being investiagted for its anti-neoplastic action [1].
The chemical structure of PLX7486 has not yet been disclosed. We will show this as soon as it is openly available. |
| References |
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1. Khotskaya YB, Holla VR, Farago AF, Mills Shaw KR, Meric-Bernstam F, Hong DS. (2017)
Targeting TRK family proteins in cancer. Pharmacol Ther, 173: 58-66. [PMID:28174090] |
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2. Vaishnavi A, Le AT, Doebele RC. (2015)
TRKing down an old oncogene in a new era of targeted therapy. Cancer Discov, 5 (1): 25-34. [PMID:25527197] |
