Ligand id: 9207

Name: 2'3'-cGAMP

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 23
Hydrogen bond donors 8
Rotatable bonds 2
Topological polar surface area 344.65
Molecular weight 675.11
XLogP -6.4
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. (2013)
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Science, 339 (6121): 826-30. [PMID:23258412]
2. Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ. (2013)
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.
Mol. Cell, 51 (2): 226-35. [PMID:23747010]