dihydrexidine

Ligand id: 9267

Name: dihydrexidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 3
Rotatable bonds 0
Topological polar surface area 52.49
Molecular weight 267.13
XLogP 3.45
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Lovenberg TW, Brewster WK, Mottola DM, Lee RC, Riggs RM, Nichols DE, Lewis MH, Mailman RB. (1989)
Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist.
Eur. J. Pharmacol.166 (1): 111-3. [PMID:2572425]
2. Rosell DR, Zaluda LC, McClure MM, Perez-Rodriguez MM, Strike KS, Barch DM, Harvey PD, Girgis RR, Hazlett EA, Mailman RB et al.. (2015)
Effects of the D1 dopamine receptor agonist dihydrexidine (DAR-0100A) on working memory in schizotypal personality disorder.
Neuropsychopharmacology40 (2): 446-53. [PMID:25074637]