dihydrexidine

Ligand id: 9267

Name: dihydrexidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 3
Rotatable bonds 0
Topological polar surface area 52.49
Molecular weight 267.13
XLogP 3.45
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(6aS,12bR)-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
Synonyms
DAR 0100A | DAR-0100A | DAR0100A
Database Links
CAS Registry No. 137417-08-4
GtoPdb PubChem SID 315661342
PubChem CID 5311070
Search Google for chemical match using the InChIKey BGOQGUHWXBGXJW-YOEHRIQHSA-N
Search Google for chemicals with the same backbone BGOQGUHWXBGXJW
Search UniChem for chemical match using the InChIKey BGOQGUHWXBGXJW-YOEHRIQHSA-N
Search UniChem for chemicals with the same backbone BGOQGUHWXBGXJW
Comments
Dihydrexidine is a moderately selective full agonist at the dopamine D1 and D5 receptors. Currently undergoing clinical trials to assess its efficacy in improving the cognitive and working memory deficits in schizophrenia and schizotypal disorder. Results of a proof-of-principle study are reported in [2].