deflazacort

Ligand id: 9477

Name: deflazacort

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 102.26
Molecular weight 441.22
XLogP 1.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Griggs RC, Miller JP, Greenberg CR, Fehlings DL, Pestronk A, Mendell JR, Moxley 3rd RT, King W, Kissel JT, Cwik V et al.. (2016)
Efficacy and safety of deflazacort vs prednisone and placebo for Duchenne muscular dystrophy.
Neurology87 (20): 2123-2131. [PMID:27566742]
2. Luzzani F, Glässer A. (1981)
Differential binding in vitro to glucocorticoid receptors of deflazacort and prednisolone.
Eur. J. Pharmacol.76 (4): 427-30. [PMID:7327211]
3. Möllmann H, Hochhaus G, Rohatagi S, Barth J, Derendorf H. (1995)
Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone.
Pharm. Res.12 (7): 1096-100. [PMID:7494809]