Abbreviated name: 3AC
Synonyms: 3 α-aminocholestane
Compound class:
Synthetic organic
Comment: 3AC is an inhibitor of inositol polyphosphate-5-phosphatase D (INPP5D) [1], an enzyme with a role in controlling immune regulatory cell numbers in vivo. INPP5D is more commonly referred to as SHIP1. SHIP1 inhibitors are being investigated as novel agents with potential clinical application in allogeneic transplantation and the treatment of hematologic malignancies.
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References |
1. Brooks R, Fuhler GM, Iyer S, Smith MJ, Park MY, Paraiso KH, Engelman RW, Kerr WG. (2010)
SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells. J Immunol, 184 (7): 3582-9. [PMID:20200281] |