AG 1295

Ligand id: 5914

Name: AG 1295

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 25.78
Molecular weight 234.12
XLogP 5.43
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
fms related tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 53.6 47.0 25.0
KIT proto-oncogene receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 63.5 86.0 70.0
NIMA related kinase 2 NEK2/NEK2 Hs Inhibitor Inhibition 75.7 92.0 105.0
fibroblast growth factor receptor 4 FGFR4/FGFR4 Hs Inhibitor Inhibition 77.2 134.0 93.0
glycogen synthase kinase 3 beta GSK3β/GSK3b Hs Inhibitor Inhibition 79.5 88.0 106.0
serine/threonine kinase 17a DRAK1/DRAK1(STK17A) Hs Inhibitor Inhibition 80.0 70.0 95.0
MAP kinase interacting serine/threonine kinase 1 nd/MNK1 Hs Inhibitor Inhibition 80.3
Pim-2 proto-oncogene, serine/threonine kinase Pim-2/PIM2 Hs Inhibitor Inhibition 81.0 126.0 115.0
CDC42 binding protein kinase alpha MRCKα/MRCKa(CDC42BPA) Hs Inhibitor Inhibition 81.2 114.0 81.0
MER proto-oncogene, tyrosine kinase Mer/c-MER Hs Inhibitor Inhibition 81.4 107.0 90.0
Displaying the top 10 targets  View all targets in screen »