aurora kinase inhibitor III

Ligand id: 5931

Name: aurora kinase inhibitor III

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 78.94
Molecular weight 413.15
XLogP 5.41
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
tyrosine kinase 2 nd/TYK2 Hs Inhibitor Inhibition 42.5
LIM domain kinase 1 LIMK1/LIMK1 Hs Inhibitor Inhibition 45.1 30.0 13.5
Janus kinase 2 JAK2/JAK2 Hs Inhibitor Inhibition 47.7 18.0 18.5
FYN proto-oncogene, Src family tyrosine kinase Fyn/FYN Hs Inhibitor Inhibition 54.1 46.5 5.5
colony stimulating factor 1 receptor Fms/FMS Hs Inhibitor Inhibition 63.1 22.0 2.5
SRC proto-oncogene, non-receptor tyrosine kinase cSrc/c-SRC Hs Inhibitor Inhibition 64.5 64.0 8.5
c-ros oncogene 1, receptor tyrosine kinase Ros/ROS(ROS1) Hs Inhibitor Inhibition 65.5 102.5 71.5
tyrosine kinase non receptor 2 ACK1/ACK1 Hs Inhibitor Inhibition 66.5 24.5 3.5
aurora kinase A Aurora-A/Aurora A Hs Inhibitor Inhibition 67.0 22.5 18.0
NUAK family kinase 1 ARK5/ARK5(NUAK1) Hs Inhibitor Inhibition 67.2 29.0 38.5
Displaying the top 10 targets  View all targets in screen »