BAY 11-7082

Ligand id: 5934

Name: BAY 11-7082

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 66.31
Molecular weight 207.04
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 70.6 88.0 93.0
mitogen-activated protein kinase 8 JNK1α1/JNK1 Hs Inhibitor Inhibition 74.7 115.0 96.0
protein kinase N2 PRK2/PKN2(PRK2) Hs Inhibitor Inhibition 81.5 90.0 87.0
tyrosine kinase 2 nd/TYK2 Hs Inhibitor Inhibition 82.8
ribosomal protein S6 kinase A4 MSK2/MSK2(RPS6KA4) Hs Inhibitor Inhibition 82.8 105.0 99.0
PDZ binding kinase nd/PBK(TOPK) Hs Inhibitor Inhibition 83.2
serine/threonine kinase 39 nd/STK39(STLK3) Hs Inhibitor Inhibition 83.7
homeodomain interacting protein kinase 2 HIPK2/HIPK2 Hs Inhibitor Inhibition 83.9 101.0 96.0
TANK binding kinase 1 TBK1/TBK1 Hs Inhibitor Inhibition 83.9 87.0 81.0
microtubule affinity regulating kinase 2 PAR-1Bα/MARK2(PAR-1Ba) Hs Inhibitor Inhibition 84.0 106.0 90.0
Displaying the top 10 targets  View all targets in screen »