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Synonyms: rhC1INH | Ruconest®
conestat alfa is an approved drug (EMA (2010), FDA (2014))
Compound class:
Peptide or derivative
Comment: Conestat alfa is a recombinant analogue of the human C1 esterase inhibitor produced by recombinant DNA technology (in transgenic rabbits). The protein sequence of the enzyme peptide chain is identical to the endogenous human enzyme encoded by the SERPING1 gene (P05155) [1], but it lacks the 22 amino acid signal peptide.
Three nanofiltered/virus filtered, pasteurized, human plasma–derived C1 esterase inhibitor concentrates are already approved by international approval agencies; Berinert® (eMC link), Cetor® (available in the Netherlands and Turkey) and Cinryze® (EMA link). |
Peptide Sequence  |
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NPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPILEVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQP TQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVL LGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELI NTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKA KVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFS YDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFVLWDQQHKFPVFMGRVYDPRA |
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| Post-translational Modification | |
| Heavily glycosylated, and forms two intramolecular di-sulphide bonds (see P05155 for sequence and modification positions). | |
